What discovery companies need from external partners

The rise in the importance of out-sourcing has been one of the most dramatic changes in the drug discovery landscape over the past 20 years. SMEs requiring to out-source some or all of their activities need flexible, responsive partners focussed on providing them with the clear solutions they need to move their programmes forward.

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Mark PortsmouthComment
Discovery Formulation

In this article I have discussed several aspects of Formulation in a Drug Discovery setting. This includes screening, stability and solubility for solution and suspension formulations. The related area of analysis of dosing solutions and suspensions to support both PK and PD studies is also covered. For suspension formulations, it is possible to generate information relating to their homogeneity and the degree of solubility of the drug substance, both of which may have an important bearing on biological effects.

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Stability Matters in Drug Discovery

In this article I have discussed several types of stability assay important in Drug Discovery including stability in simple buffer systems at various pH values, two approaches to photostability and its relationship with phototoxicity, glutathione reactivity and chiral stability assays.

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Mark PortsmouthComment
Guidelines for the Quality of Compounds from Medicinal Chemistry

In this article I have discussed issues around registration of Medicinal Chemistry compounds including who does it and who checks it; QC of DMSO stock solutions to assure the accuracy of the Compound Management processes as well as stability of compounds in solution and what is required to generate a Certificate of Analysis for those compounds progressing to key studies that necessitate one. Finally, what does purity even mean?

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Mark PortsmouthComment