The 3rd Cambridge Area Analytical Chemistry Group Meeting

… was held on 26 April at GSK’s Medicines Research Centre in Stevenage with the topic of

Advancing established analytical techniques to meet the demands of modern drug discovery

The Group is an opportunity for local Analytical Chemists to meet and exchange ideas on the many common areas of their work.  Previous meetings focusing on Open Access and Purification have been generously supported by AstraZeneca and Charles River and thanks go out to them along with GSK for allowing this to happen.  In particular, for this meeting, Tim Underwood of GSK did a great job with the organisation.

More than 40 delegates turned out to hear a full and varied programme of speakers in an informal atmosphere.

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Visit to Immundnz in February 2018

I recently had the pleasure of visiting Immundnz, a young company based in the BioHub at Alderley Park in Cheshire. My hosts were the two founders of the company, Dr Masih Alam and Dr Robert-Jan Lamers.

The company was founded in 2016 to provide specialised support in immunology. They use an array of cellular, immunologic and molecular methods to build up a comprehensive picture of drug-induced immunogenicity.

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Innovative Software to maximise LC(MS) productivity for physico-chemical measurements

A pharmaceutical physical chemistry group will typically run a variety of assays such as chemical stability, solubility, lipophilicity measurement, PAMPA and binding assays. With the high cost of ownership of LC(MS) systems there is always a need to maximise the return on investment in these systems by running as many different assays on the minimum number of systems to take full advantage of their inherent speed and versatility.

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Validation of a PAMPA permeability assay

Over recent weeks I have been working to establish a suite of assays using my own UHPLC instrumentation.  LogD, solubility and PAMPA permeability measurement are all now available to clients via out-sourcing, in-sourcing or consultancy to set up the methods in your laboratory which can also include bespoke software. Here I am presenting some validation data to support the use of my PAMPA method.

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Validation of a Chromatographic method for LogD measurement

This blog returns to the familiar theme of physico-chemical measurement.  Over recent weeks I have been working to establish a suite of assays using my own UHPLC instrumentation.  LogD, solubility and PAMPA permeability measurement are all now available to clients via out-sourcing, in-sourcing or consultancy to set up the methods in your laboratory which can also include bespoke software. Here I am presenting some validation data to support the use of my LogD7.4 method.

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Antibody analysis using High Performance Capillary Electrophoresis (HPCE)

This post features some data generated by deltaDOT Ltd using HPCE for the analysis of the monoclonal antibodies Infliximab and Rituximab. Stability, fragmentation and charge heterogeneity were assessed using a combination of Capillary Gel Electrophoresis (CGE) and Capillary Zone Electrophoresis (CZE). Quantifiable differences were observed in the samples before and after heat-stress. Excellent repeatability was obtained. This work was performed as part of a study for the UK’s National Health Service (NHS).

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What discovery companies need from external partners

The rise in the importance of out-sourcing has been one of the most dramatic changes in the drug discovery landscape over the past 20 years. SMEs requiring to out-source some or all of their activities need flexible, responsive partners focussed on providing them with the clear solutions they need to move their programmes forward.

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